Results
| PMID | 12903034 |
| Gene Name | CYP1A1 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | CYP1A1 (exon 7 A4889G locus) |
| Population size | 156 |
| Population details | 156 (76 patients with endometriosis, 80 healthy controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Aug;20(4):284-6. Peng, Dong-xian| He, Yuan-li| Qiu, Li-wen| Yang, Fang| Lin, Jing-ming Department of Gynecology and Obstetrics, Zhujiang Hospital, First Military Medical University, Guangzhou, Guangdong, 510282 PR China. pengdx@hotmail.com OBJECTIVE: To assess the possible association between gene mutation of cytochrome P450 1A1(CYP1A1) in exon 7 A4889G locus and the susceptibility to endometriosis (EM). METHODS: Allele specific-polymerase chain reaction method was used to analyze gene mutation in exon 7 A4889G locus of CYP1A1 in 76 patients with endometriosis and 80 healthy controls. RESULTS: The frequency of allele G on A4889G locus of CYP1A1 gene showed a significant difference between the study cohort and the control group (Chi2=7.498, P<0.01), with an odds ratio of 1.957. Statistically significant difference in the frequencies of genotypes AA, AG and GG was observed between the two groups (Chi2=6.915, P<0.05). Individuals with homozygotes for G allele were at higher risk of suffering from EM when compared against those with homozygotes for A allele, the odds ratio being 3.437 (Chi2=5.430, P<0.05). CONCLUSION: The above results suggest that gene mutation of CYP1A1 in exon 7 A4889G locus might be a genetic susceptible factor of endometriosis. The mutation allele of CYP1A1 gene appears to increase the risk of endometriosis. Mesh Terms: Alleles| Cytochrome P-450 CYP1A1/*genetics| Endometriosis/*genetics| Exons/*genetics| Female| Genetic Predisposition to Disease/genetics| Genotype| Humans| *Mutation| Polymerase Chain Reaction| Pregnancy|DA 2009/03/04 09:00 |
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